Record Details

Antidiabetic and antioxidant potential of ethanolic extract of Butea monosperma leaves in alloxan-induced diabetic mice

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Antidiabetic and antioxidant potential of ethanolic extract of Butea monosperma leaves in alloxan-induced diabetic mice
 
Creator Sharma, Nidhi
Garg, Veena
 
Subject Butea monosperma leaves
Diabetes mellitus
Oxidative stress
Alloxan
Antidiabetic
Antioxidant potential
 
Description 99-105
The possible protective effect of ethanolic extract of B. monosperma leaves (BMEE) on diabetes and diabetes-induced oxidative stress was evaluated in alloxan (ALXN)-induced diabetic male adult mice. Experimental animals were divided into three groups viz., I, II, and III. Diabetes mellitus (DM) was induced in groups II and III mice by a single intraperitoneal injection of alloxan (150 mg/kg body wt). Group I (control mice) received an equal volume of normal saline. Group III mice were further treated with BMEE (300 mg/kg body wt, p.o.) for a period of 45 days. Body weight and fasting blood glucose (FBG) levels were measured at periodic intervals during the test period. At the end of treatment period, blood was collected by cardiac puncture under mild ether anesthesia and serum was isolated to analyze its lipid profile i.e. serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL). The homogenates of hepatic, pancreatic and renal tissues were also analyzed for both enzymatic and non-enzymatic antioxidants, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and total protein (TP). Alloxan injection resulted in a significantly (P
 
Date 2009-03-05T05:09:03Z
2009-03-05T05:09:03Z
2009-02
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3324
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.46(1) [February 2009]