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Embryo protective effect of pomegranate (Punica granatum L.) fruit extract in adriamycin-induced oxidative stress

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Title Embryo protective effect of pomegranate (Punica granatum L.) fruit extract in adriamycin-induced oxidative stress
 
Creator Kishore, R Krishna
Sudhakar, D
Parthasarathy, P R
 
Subject Adriamycin
Amniotic fluid
Biochemical parameters
Chick embryo
 
Description 106-111
The possible protective role of pomegranate (Punica granatum L.) fruit extract which has shown antioxidant capacity higher than that of red wine and green tea was evaluated against adriamycin-induced oxidative stress in chick embryos. Adriamycin (ADR), an anthracycline broad spectrum of chemotherapeutic drug is used for the treatment of variety of cancers; however, its prolonged use is limited by an irreversible, dose-dependant and progressive cardiomyopathy, hepatotoxicity and general toxicity to other organs in human beings, due to oxidative stress. The morphological changes (malformation of different organs), changes in body weight, volume of amniotic fluid (AF) and biochemical parameters of AF were studied after 24 and 48 h of incubation by comparing ADR alone and pomegranate fruit extract pretreated groups with their respective controls of 12 days old chick embryos. ADR alone at a dose of 70 μg/egg showed a significant dose versus time- dependent reduction in body weight, volume of AF. A dose-related increase in embryo gross morphological deformities and significant changes in the levels of biochemical parameters in AF were observed in ADR-treated group. These changes were significantly ameliorated to normal by pre-administration of pomegranate fruit extract at a dose of
200 µg/egg. Thus, the present study demonstrated the embryo protective nature of pomegranate fruit extract against ADR-induced oxidative stress.
 
Date 2009-03-05T06:25:13Z
2009-03-05T06:25:13Z
2009-02
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3330
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.46(1) [February 2009]