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Time-dependent effects of ethanol on blood oxidative stress parameters and cytokines

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Title Time-dependent effects of ethanol on blood oxidative stress parameters and cytokines
 
Creator Das, Subir Kumar
Varadhan, Sowmya
Gupta, Geetanjali
Mukherjee, Sukhes
Dhanya, L
Rao, D N
Vasudevan, D M
 
Subject Cytokines
Ethanol
Interleukin
Liver
Oxidative stress
 
Description 116-121
Alcohol consumption is implicated in the genesis of a spectrum of liver abnormalities, which are associated with a number of factors. In the present study, time-dependent effects of ethanol on cytokines (TNF-α, IL-2, IL-4, IL-10, IFN-ϒ, VEGF-A and TGF-β1) in serum, and blood oxidative stress parameters such as reduced glutathione content, TBARS level and activities of GPx, GR, GST, catalase and SOD in 8-10 weeks-old male BALB/c mice have been investigated. Ethanol administered @1.6 g/kg body wt/day significantly increased the activities of liver marker enzymes AST, ALT and ALP. Serum nitrite levels and haemolysate TBARS level also increased, while total antioxidant status in serum and GSH content in whole blood hemolysate decreased from 4th week onwards of exposure. Inspite of the increased serum nitrite level and GST activity in the haemolysate, albumin level in serum, GPx and GR activities in haemolysate decreased after 12 weeks of exposure. Chronic ethanol treatment did not show any effect on IL-2, but IL-4 level was reduced and other cytokines such as IL-10, TNF-α, IFN-ϒ, TGF-β1 and VEGF-A levels were increased significantly after 12 weeks. The study indicates a relationship between free radical generation and immune response, and suggests that ethanol-induced liver damage is associated with oxidative stress and immunological alterations in a time-dependent manner.
 
Date 2009-03-05T05:09:36Z
2009-03-05T05:09:36Z
2009-02
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3327
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.46(1) [February 2009]