Hypolactasia as a molecular basis of lactose intolerance
NOPR - NISCAIR Online Periodicals Repository
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Title |
Hypolactasia as a molecular basis of lactose intolerance
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Creator |
Kaur, Kamaljit
Mahmood, Safrun Mahmood, Akhtar |
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Subject |
Lactase-phlorizin hydrolase
Lactase activity Adult-type hypolactasia Lactase glycosylation and regulation Lactose intolerance Lactose gene expression |
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Description |
267-274
Lactase-phlorizin hydrolase (LPH), a membrane-bound glycoprotein present in the luminal surface of enterocytes in the intestine is responsible for lactose intolerance, a phenomenon prevalent in humans worldwide. In the rodent intestine, the post-natal development of the LPH follows a specific pattern, such that the enzyme levels are high in the peri-natal period, but declines considerably upon maturation. The observed maturational decline in the LPH activity is very similar to adult-type hypolactasia observed in humans. Majority of the studies have been carried out using animal models or cell lines and a number of hypotheses have been put forward to explain the maturational decline of lactase activity such as: (a) decreased amount of lactase protein, (b) defect in post-translational modification of precursor lactase to the mature enzyme, and (c) synthesis of an inactive, high molecular weight lactase with altered glycosylation, however, the precise underlying mechanism of adult-type hypolactasia remains undefined. The present review describes the recent developments in understanding the regulation of lactase expression and the possible mechanism of adult-type hypolactasia, as a cause of lactose intolerance. |
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Date |
2009-03-20T04:51:29Z
2009-03-20T04:51:29Z 2006 |
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Type |
Article
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Identifier |
0301-1208
http://hdl.handle.net/123456789/3406 |
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Language |
en_US
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Publisher |
csir
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Source |
IJBB Vol.43(5) [October 2006]
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