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Acute effects of a partially purified fraction from garlic on plasma glucose and cholesterol levels in rats: Putative involvement of nitric oxide

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Title Acute effects of a partially purified fraction from garlic on plasma glucose and cholesterol levels in rats: Putative involvement of nitric oxide
 
Creator Mehrzia, Mokni
Ferid, Limam
Mohamed, Amri
Ezzedine, Aouani
 
Subject Garlic
Rat
Glucose
Cholesterol
Insulinemia
Nitric oxide
 
Description 386-390
Garlic has been extensively used as a medicinal plant. Most of its numerous beneficial effects such as antioxidant, antibacterial, antitumoral involve sulfur-derived amino acids. In the present work, we reevaluated the acute effects of aqueous extract of garlic on plasma glucose and cholesterol levels in normal rats. Control (vehicle H2O) or garlic extract-treated group at 100-120 mg protein/kg body wt were intraperitoneally injected (IP) and glucose, cholesterol, insulin and nitric oxide metabolites levels were determined after a short-term duration of 6 h. We confirmed that garlic contained an active fraction, exerting both glucose and cholesterol-lowering activity. The glucose-lowering effect was triggered by an increase in insulinemia. Preliminary study indicated that the active agent was different from S-allyl-cysteine-sulfoxide, the active principle implicated in hypoglycaemic and hypolipidemic effects of garlic or arginine. The mechanism of action seemed to involve nitric oxide (NO), which increased time and dose-dependently. The garlic effects were abolished by diphenyleneiodonium chloride (DPI = 1 mg/kg body wt), a specific inhibitor of NO production, suggesting the involvement of constitutive nitric oxide synthase.
 
Date 2009-03-20T08:14:11Z
2009-03-20T08:14:11Z
2006
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3414
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.43(6) [December 2006]