Record Details

Synthesis, analgesic and anti-inflammatory activities of bis(indolyl)methanes

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Synthesis, analgesic and anti-inflammatory activities of bis(indolyl)methanes
 
Creator Sujatha, Kuppusamy
Perumal, Paramasivan T.
Muralidharan, Doraisamy
Rajendran, Melani
 
Subject Bis(indolyl)methanes
Acute toxicity
Analgesic
Anti-inflammatory
Ulcerogenic activity
 
Description 267-272
A series of bis(indolyl)methanes have been synthesized by stirring a mixture of indole and aldehydes in methanol:water (1:1 v/v) containing catalytic amount of sodium bisulphite at RT. Acute toxicity, analgesic, anti-inflammatory and ulcerogenic activities of the prepared bis(indolyl)methanes are evaluated in vivo in comparison to standard drugs (ibuprofen and indomethacin). In acute toxicity study, no mortality is observed in the tested compounds and compound 3c is found to be safe. All the tested compounds show significant analgesic and anti-inflammatory activity without an ulcerogenic activity. The most active compounds of this series are 3c and 3d.
 
Date 2009-03-23T04:31:28Z
2009-03-23T04:31:28Z
2009-02
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/3432
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.48B(2) [February 2009]