Synthesis, anti-inflammatory and analgesic activity evaluation of some pyrimidine derivatives
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Title |
Synthesis, anti-inflammatory and analgesic activity evaluation of some pyrimidine derivatives
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Creator |
Sondhi, Sham M
Dinodia, Monica Rani, Reshma Shukla, Rakesh Raghubir, Ram |
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Subject |
Pyrimidines
Carrageenan Anti-inflammatory Analgesic |
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Description |
273-281
A number of pyrimidine derivatives 1-3, 5-19 have been synthesized by condensation of bis(2-(vinyloxy))ethylamine, cyclopropylamine, N-(2-amino-4-ethoxyphenyl)acetamide, 2-(aminomethyl thiophene), 2-thiophen ethylamine, 2-hydrazinopyridine, 1-aminonaphthalen-2-ol hydrochloride, furfuryl amine, 2-(4-imidazolyl)ethylamine, 2-picolylamine and 4-methoxyl-2-nitroaniline with various isothiocyanatoketones. These compounds have been screened for anti-inflammatory and analgesic activities. Compounds 10 and 14 have exhibited 40% and 39% anti-inflammatory and compound 11 has showed 75% analgesic activity at 100 mg/kg p.o. respectively. |
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Date |
2009-03-23T04:15:12Z
2009-03-23T04:15:12Z 2009-02 |
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Type |
Article
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Identifier |
0376-4699
http://hdl.handle.net/123456789/3429 |
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Language |
en_US
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Publisher |
CSIR
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Source |
IJCB Vol.48B(2) [February 2009]
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