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Synthesis, anti-inflammatory and analgesic activity evaluation of some pyrimidine derivatives

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Title Synthesis, anti-inflammatory and analgesic activity evaluation of some pyrimidine derivatives
 
Creator Sondhi, Sham M
Dinodia, Monica
Rani, Reshma
Shukla, Rakesh
Raghubir, Ram
 
Subject Pyrimidines
Carrageenan
Anti-inflammatory
Analgesic
 
Description 273-281
A number of pyrimidine derivatives 1-3, 5-19 have been synthesized by condensation of bis(2-(vinyloxy))ethylamine, cyclopropylamine, N-(2-amino-4-ethoxyphenyl)acetamide, 2-(aminomethyl thiophene), 2-thiophen ethylamine,
2-hydrazinopyridine, 1-aminonaphthalen-2-ol hydrochloride, furfuryl amine, 2-(4-imidazolyl)ethylamine, 2-picolylamine and 4-methoxyl-2-nitroaniline with various isothiocyanatoketones. These compounds have been screened for
anti-inflammatory and analgesic activities. Compounds 10 and 14 have exhibited 40% and 39% anti-inflammatory and compound 11 has showed 75% analgesic activity at 100 mg/kg p.o. respectively.
 
Date 2009-03-23T04:15:12Z
2009-03-23T04:15:12Z
2009-02
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/3429
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.48B(2) [February 2009]