Synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles
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Title |
Synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles
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Creator |
Mogilaiah, K
Vidya, K Kavitha, S Kumar, K Shiva |
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Subject |
2-Hydrazino-3-(3-chlorophenyl)-1,8-naphthyridine
Acetophenones 1,8-naphthyridin-2-ylhydrazones Vilsmeier-Haack reagent 1,8-naphthyridinyl-pyrazoles |
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Description |
282-285
Condensation of 2-hydrazino-3-(3-chlorophenyl)-1,8-naph¬thyridine 2 with different acetophenones in methanol containing a catalytic amount of glacial acetic acid affords the corresponding aceto¬phenone 3-(3-chlorophenyl)-1,8-naphthyridin-2-ylhydra¬zones 3 in excellent yields. The hydrazones 3 when subjected to the Vilsmeier-Haack reaction with POCl₃-DMF gives 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles 4 in good yields. The structural assignments to compounds 3 and 4 are based on their elemental analyses and spectral data. Compounds 4 have been tested for their antibacterial activity. |
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Date |
2009-03-23T04:15:35Z
2009-03-23T04:15:35Z 2009-02 |
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Type |
Article
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Identifier |
0376-4699
http://hdl.handle.net/123456789/3430 |
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Language |
en_US
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Publisher |
CSIR
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Source |
IJCB Vol.48B(2) [February 2009]
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