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Synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles

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Title Synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles
 
Creator Mogilaiah, K
Vidya, K
Kavitha, S
Kumar, K Shiva
 
Subject 2-Hydrazino-3-(3-chlorophenyl)-1,8-naphthyridine
Acetophenones
1,8-naphthyridin-2-ylhydrazones
Vilsmeier-Haack reagent
1,8-naphthyridinyl-pyrazoles
 
Description 282-285
Condensation of 2-hydrazino-3-(3-chlorophenyl)-1,8-naph¬thyridine 2 with different acetophenones in methanol containing a catalytic amount of glacial acetic acid affords the corresponding aceto¬phenone 3-(3-chlorophenyl)-1,8-naphthyridin-2-ylhydra¬zones 3 in excellent yields. The hydrazones 3 when subjected to the Vilsmeier-Haack reaction with POCl₃-DMF gives 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles 4 in good yields. The structural assignments to compounds 3 and 4 are based on their elemental analyses and spectral data. Compounds 4 have been tested for their antibacterial activity.
 
Date 2009-03-23T04:15:35Z
2009-03-23T04:15:35Z
2009-02
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/3430
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.48B(2) [February 2009]