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Biochemical changes in erythrocyte membrane in uncontrolled type 2 diabetes mellitus

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Title Biochemical changes in erythrocyte membrane in uncontrolled type 2 diabetes mellitus
 
Creator Reshamwala, Shamlan M S
Patil, Neela D
 
Subject Uncontrolled type 2 diabetes mellitus
Erythrocyte membrane
Glycated haemoglobin
Na⁺-K⁺-ATPase
Mg²⁺-ATPase
Lipid peroxidation
Cholesterol
Phospholipid
 
Description 250-253
The levels of lipid peroxidation and alterations in lipid composition and ATPase activities were determined in erythrocyte plasma membrane of uncontrolled type 2 diabetes mellitus (DM) patients. The study groups consisted of 30 patients (16 males, 14 females) attending the Out Patients’ Department of Lokmanya Tilak Municipal General Hospital, Mumbai, and 23 age- and sex-matched control subjects (15 males, 8 females). Glycated haemoglobin (an index of long-term glycaemic control), erythrocyte membrane cholesterol, phospholipid and cholesterol to phospholipid molar ratio, lipid peroxidation products in the form of thiobarbituric acid-reactive substances (TBARS), and Na⁺-K⁺-ATPase activity were found to be significantly increased, and Mg²⁺-ATPase activity significantly decreased, in the diabetic subjects, as compared to controls. The study suggests that biochemical changes in the erythrocyte membrane may be involved in the pathophysiology of type 2 DM.
 
Date 2009-03-30T08:44:10Z
2009-03-30T08:44:10Z
2005-08
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3531
 
Language en_US
 
Relation A61K38/42; A61P7/00
 
Publisher CSIR
 
Source IJBB Vol.42(4) [August 2005]