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Evidence of free radical participation in N-glycolylneuraminic acid generation in liver of chicken treated with gallotannic acid

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Title Evidence of free radical participation in N-glycolylneuraminic acid generation in liver of chicken treated with gallotannic acid
 
Creator Mwangi, Danny W
Bansal, Devi D
 
Subject Gallotannic acid
N-glycolylneuraminic acid
Oxidative stress
 
Description 20-28
The occurrence of N-glycolylneuraminic acid (Neu5Gc) in cancerous tissue and inflammatory diseases, conditions associated with increased oxidative stress suggests the participation of reactive oxygen radicals in Neu5Gc generation, where an oxygen atom is transferred. To study this possibility, we treated two groups of domesticated birds and rabbits with different dosages of gallotannic acid (GTA), a compound known to cause generation of reactive oxygen species (ROS). The antioxidant status and leukocyte capacity, as well as amount and form of sialic acids were assessed in plasma and liver. Results showed that while lipid peroxides were increased, white blood cell (WBC) count was decreased significantly in all treated groups. The increased sialic acids and low protein contents were observed in plasma, possibly as a result of decreased sialic acid cycling crucial for formation of new glycoconjugates in tissues, caused by decreased protein synthesis due to microsomal degranulation. The activities of antioxidant enzymes were also decreased in treated groups, implying increased oxidative stress. The presence of Neu5Gc and apparent absence of Neu5Ac hydroxylase activity in liver of chicken treated with GTA indicate that free radicals might be involved in the non-enzymatic hydroxylation of
N-acetylneuraminic acid (Neu5Ac) to Neu5Gc in liver, which normally does not express this sialic acid.
 
Date 2009-03-31T06:08:40Z
2009-03-31T06:08:40Z
2004-02
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3633
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol. 41(1) [February 2004]