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Antitumour activity of Annona squamosa seed extracts is through the generation of free radicals and induction of apoptosis

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Title Antitumour activity of Annona squamosa seed extracts is through the generation of free radicals and induction of apoptosis
 
Creator Pardhasaradhi, B V V
Reddy, Madhurima
Ali, A Mubarak
Kumari, A Leela
Khar, Ashok
 
Subject Annona squamosa
reactive oxygen species (ROS)
GSH
antitumour activity
apoptosis
Bcl-2
seed extract
 
Description 167-172
The plant, Annona squamosa traditionally known as custard apple possesses potent bioactive principles in all its parts. The effect of aqueous and organic extracts from defatted seeds of A. squamosa was studied on a rat histiocytic tumour cell line, AK-5. Both the extracts caused significant apoptotic tumour cell death with enhanced caspase-3 activity, down regulation of antiapoptotic genes Bcl-2 and BclXL, and enhanced the generation of intracellular ROS, which correlated well with the decreased levels of intracellular GSH. In addition, DNA fragmentation and annexin-V staining confirmed that the extracts induced apoptosis in tumour cells through the oxidative stress. Aqueous extracts of A. squamosa seeds possessed significant antitumor activity in vivo against AK-5 tumor.
 
Date 2009-04-02T06:16:31Z
2009-04-02T06:16:31Z
2004-08
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3703
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.41(4) [August 2004]