Record Details

Polyunsaturated fatty acids inhibit mouse hepatic glucocorticoid receptor activation in vitro

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Polyunsaturated fatty acids inhibit mouse hepatic glucocorticoid receptor activation in vitro
 
Creator Ranhotra, H S
Sharma, R
 
Subject Fatty acids
mice
liver
activation
glucocorticoid receptor
 
Description 246-249
The effect of saturated fatty acids (SFAs) stearic and palmitic acids and polyunsaturated fatty acids (PUFAs) oleic, linoleic and arachidonic acids was studied on in vitro heat activation of mouse hepatic glucocorticoid receptor (GR) complex, as assessed by binding to DNA-cellulose and purified nuclei. Significant dose-dependent inhibition of heat activation of hormone-receptor com-plex by the PUFAs was observed. Linoleic and arachidonic acids were found to be more potent (caused ~70% inhibition maximally at 160 μM) inhibitors of GR heat activation, compared to oleic acid (~38% inhibition at 40 μM). However, stearic and palmitic acids were unable to modulate GR heat activation, suggesting that the unsaturated moieties in PUFAs are possibly the important determinants of receptor activation. Thus, our study shows an inhibitory effect of PUFAs on in vitro hepatic GR activation.
 
Date 2009-04-02T08:53:10Z
2009-04-02T08:53:10Z
2004-10
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3715
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.41(5) [October 2004]