Record Details


Field	Value

Title	Computational analysis of evolutionary divergence of scorpion toxins

Creator	Upadhyay, R K

Description	51-58 Conserved and consensus sequences of several members of scorpion toxin families have been analyzed. Multiple sequence alignment define the highly conserved residues that play important structural role in formation of toxin sub-groups. Scorpion toxins have characteristic feature in signature pattern {(GA)}- K-C {(LIVM)}-X (2)- K- C- C-X-C) }, where lysine and cysteine residues are well conserved in the polypeptide. The toxins show two major groups, one with conserved active region GKCMNKGKC and second with CTPK. There is variability in position of lysine and arginine in different toxins. Most of the scorpion toxins contain six conserved cysteines involved in disulphide bonds. From the evolutionary analysis it is concluded that Leiurus is a primitive ancestral species from which probably various toxins have evolved during the evolution.

Date	2009-04-06T09:27:04Z 2009-04-06T09:27:04Z 2003-02

Type	Article

Identifier	0301-1208 http://hdl.handle.net/123456789/3740

Language	en_US

Publisher	CSIR

Source	IJBB Vol.40(1) [February 2003]

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