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Liver and colon pro- and anti-oxidant enzyme activities in rats after long-term ethylnitrosourea exposure

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Title Liver and colon pro- and anti-oxidant enzyme activities in rats after long-term ethylnitrosourea exposure
 
Creator Silig, Yavuz
Ozdemir, Ozturk
Atalay, Atilla
 
Description 136-138
Liver and colon pro- and anti-oxidant enzyme activities were investigated in rats treated with ethylnitrosourea (ENU) (i.p.) (4 mg/kg body wt) for 6 months. The pro-oxidant enzymes (NADPH cytochrome c reductase, NADH cytochrome c reductase, NADH cytochrome b5 reductase and cytochrome P-4502E1 and the anti-oxidant enzyme, superoxide dismutase (SOD) exhibited significantly increased activity in liver and colon. Glucose-6-phosphate dehydrogenase (G6PDH) and glutathione-S-transferase (GST) showed enhanced activity in liver, but decreased activity in colon. Glutathione peroxidase (GP) and glutathione reductase (GR) activities were significantly increased in colon, but decreased in liver. Catalase (CAT) activity while showed a significant increase in liver, exhibited only marginal increase in colon. Malondialdehyde (MDA) level was significantly elevated in both tissues.
 
Date 2009-04-06T10:24:47Z
2009-04-06T10:24:47Z
2003-04
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3750
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.40(2) [April 2003]