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Delivery in vivo of 14-deoxy-11-oxoandrographolide, an antileishmanial agent, by different drug carriers

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Title Delivery in vivo of 14-deoxy-11-oxoandrographolide, an antileishmanial agent, by different drug carriers
 
Creator Lala, S
Nandy, A K
Mahato, S B
Basu, M K
 
Subject Andrographis paniculata
antileishmanial compound
14-deoxy-11-oxoandrographolide
drug carriers
in vivo delivery
liposomes
microspheres
niosomes
 
Description 169-174
An antileishmanial compound, 14-deoxy-11-oxo-andrographolide, a derivative of andrographlide, isolated from the Indian medicinal plant Andrographis paniculata was evaluated for efficacy in free form and in different vesicular delivery modes on hamster model of Leishmaniasis. The subcutaneous injection of free drug reduced the spleen parasite load by 39%, whereas for drug incorporated in liposomes, niosomes and microspheres, reductions in the parasite load were 78%, 91% and 59%, respectively. Moreover, the drug in various delivery modes, particularly in liposomal and niosomal forms, showed no apparent immediate toxicity. Although an inverse linear relationship between the size of carriers and per cent efficacy in reduction of spleen parasite load was established, involvement of other factors such as drug release profiles or rates remains an open question. Because of greater efficacy and lesser toxicity, liposomal, niosomal and possibly microsphere-incorporated 14-deoxy-11-oxo-andrographolide might have clinical application to combat visceral Leishmaniasis.
 
Date 2009-04-08T04:06:05Z
2009-04-08T04:06:05Z
2003-06
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3754
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.40(3) [June 2003]