Record Details

QSAR of peripheral benzodiazepine receptor ligand 2-phenylimidazo- [1,2-a]pyridine derivatives with physico-chemical parameters

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title QSAR of peripheral benzodiazepine receptor ligand 2-phenylimidazo- [1,2-a]pyridine derivatives with physico-chemical parameters
 
Creator Roy, Kunal
De, A U
Sengupta, Chandana
 
Description 203-208
QSAR of the binding affinities of [2-phenylimidazo[1,2-a]pyridin-3-yl]acetamide derivatives (Fig. 1) with central and peripheral (from cortex and ovary) benzodiazepine receptors has been explored using physico-chemical parameters. Attempt has been made to explore the structural and/or physico-chemical requirements of the compounds that are responsible for the selective action against peripheral benzodiazepine receptors over central ones. The results indicate that the presence of bi-substitution on the carboxamido nitrogen, presence of substitutions at X and Y positions, especially, chloro substitution at X position, and presence of chloro substitution at Z position in presence of lipophilic X and/or Y substitutions increase selectivity for binding affinity with peripheral benzodiazepine receptors over central ones.
 
Date 2009-04-08T04:37:21Z
2009-04-08T04:37:21Z
2003-06
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3759
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.40(3) [June 2003]