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Wound healing activity of aqueous and methanolic bark extracts of Vernonia arborea Buch.-Ham. in Wistar rats

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Title Wound healing activity of aqueous and methanolic bark extracts of Vernonia arborea Buch.-Ham. in Wistar rats
 
Creator Pradhan, D
Panda, P K
Tripathy, G
 
Subject Vernonia arborea
Asteraceae
Wound healing
Bark extract
 
Description 6-11
Excision, incision and dead space wound models were used to evaluate the wound
healing activity of Vernonia arborea Buch.-Ham. on Wistar rats of either sex. In excision
wound model, treatment was continued till the complete healing of the wound whereas in incision
and dead space wound models the treatment was continued for 10 days. For topical application,
5% w/w ointment of aqueous and methanol barks extracts were prepared in 2% sodium alginate
and for oral administration suspensions containing 30 mg/ml of each of the extracts in 1% gum
tragacanth were prepared. In excision and incision wound models, the control group of animals
was left untreated and in dead space wound models the animals were treated with 1 ml of 1% gum
tragacanth/kg b.w. The healing of the wound was assessed by the rate of wound contraction, period
of epithelialisation, skin breaking strength, granulation strength, dry granulation tissue weight,
hydroxyproline estimation and histopathology of the granulation tissue. Aqueous and methanol
barks extracts promoted the wound healing activity significantly in all the wound models studied.
High rate of wound contraction, decrease in the period for epithelialisation, high skin breaking
strength and granulation strength, increase in dry granulation tissue weight, elevated hydroxyproline
content and increased collagenation in histopathological section were also observed when compared
to the control group of animals. Methanol extract possesses better wound healing property than the
aqueous extract.
 
Date 2009-04-08T09:35:10Z
2009-04-08T09:35:10Z
2009-02
 
Type Article
 
Identifier 0972-592X
http://hdl.handle.net/123456789/3765
 
Language en_US
 
Relation Int cl.8— A61K 36/00, A61P 17/02
 
Publisher CSIR
 
Source NPR Vol.8(1) [January-February 2009]