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Effect of alcoholic extract of roots of Dichrostachys cinerea Wight & Arn. against cisplatin-induced nephrotoxicity in rats

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Title Effect of alcoholic extract of roots of Dichrostachys cinerea Wight & Arn. against cisplatin-induced nephrotoxicity in rats
 
Creator Adikay, Sreedevi
Koganti, Bharathi
Prasad, KVSRG
 
Subject Dichrostachys cinerea
Nephrotoxicity
Cisplatin
Antioxidant
 
Description 12-18
The alcoholic extract of roots of Dichrostachys cinerea Wight & Arn. (200 and
400 mg/kg, p.o.) was studied for its protective effect against cisplatin-induced renal injury in rats.
Cisplatin (6mg/kg, i.p.) significantly elevated serum markers level, increased urinary protein
excretion, reduced urine to serum creatinine ratio and creatinine clearance. In curative regimen,
the alcoholic extract exhibited dose dependent protection. Animals which received prophylactic
treatment also showed partial protection against cisplatin-induced effects. Histopathological studies
substantiated the above results. Further, the alcoholic extract showed marked nitric oxide scavenging
effect and reducing power suggesting an antioxidant property. A triterpenoid, fatty acid and a
steroid were isolated from the n-hexane, ethyl acetate fractions of alcoholic extract. The results
suggested that the roots of D. cinerea showed protective effect against cisplatin-induced
nephrotoxicity which may probably be mediated by its antioxidant property.
 
Date 2009-04-08T09:35:42Z
2009-04-08T09:35:42Z
2009-02
 
Type Article
 
Identifier 0972-592X
http://hdl.handle.net/123456789/3766
 
Language en_US
 
Relation Int. cl.8— A61K 36/00, A61P 39/06
 
Publisher CSIR
 
Source NPR Vol.8(1) [January-February 2009]