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Evaluation of the immunomodulatory activity of the methanolic extract of Couroupita guianensis Aubl. flowers in rats

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Title Evaluation of the immunomodulatory activity of the methanolic extract of Couroupita guianensis Aubl. flowers in rats
 
Creator Pradhan, D
Panda, P K
Tripathy, G
 
Subject Couroupita guianensis Allergic reaction
Hemagglutination
Immunostimulant
Lecythidaceae
 
Description 37-42
Various extracts of the flowers of Couroupita guianensis Aubl. (Family-Lecythidaceae)
were evaluated for potential immunomodulatory activity using the in vitro polymorphonuclear
leukocyte function test (human neutrophils). The methanol extract was evaluated for
immunomodulatory activity in in vivo studies, using rats as the animal model. The extracts were
tested for hypersensitivity and hemagglutination reactions, using sheep red blood cells (SRBC) as
the antigen. Distilled water served as a control in all the tests. The successive methanol and water
extracts exhibited a significant increase in the percentage phagocytosis versus the control. In the
in vivo studies, the successive methanol extract was found to exhibit a dose related increase in the
hypersensitivity reaction, to the SRBC antigen, at concentration of 100 and 200 mg/kg in animal
studies. The successive methanol extract was found to stimulate cell mediated and antibody
mediated immune responses in rats. It also enhanced the phagocytic function of the human
neutrophils, in vivo.
 
Date 2009-04-08T09:36:51Z
2009-04-08T09:36:51Z
2009-02
 
Type Article
 
Identifier 0972-592X
http://hdl.handle.net/123456789/3772
 
Language en_US
 
Relation Int. cl.8— A61K 36/00, A61P 37/02
 
Publisher CSIR
 
Source NPR Vol.8(1) [January-February 2009]