Record Details

Antilithiatic activity of Hibiscus sabdariffa Linn. on ethylene glycol-induced lithiasis in rats

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Antilithiatic activity of Hibiscus sabdariffa Linn. on ethylene glycol-induced lithiasis in rats
 
Creator Betanabhatla, Kalyan S
Christina, AJM
Sundar, B Syama
Selvakumar, S
Saravanan, K Sundara
 
Subject Antilithiatic
Hibiscus sabdariffa
Roselle
Nephrolithiasis
Urolithiasis
Renal calculi
Ethylene glycol
 
Description 43-47
The ethanolic extract of leaves of Hibiscus sabdariffa Linn. (EEHS) was evaluated
for its antilithiatic activity in rats. Lithiasis was induced by oral administration of ethylene glycolated
water (0.75 %) in adult male albino Wistar rats for 28 days. The ionic chemistry of urine was
altered by ethylene glycol (EG), which elevated the urinary concentration of crucial ions, viz.
calcium, phosphate, uric acid and oxalate thereby contributing to renal stone formation. The
EEHS, however, significantly (P< 0.05) reduced the elevated level of these ions in urine. Also, it
elevated concentration of urinary magnesium, which is considered as one of the inhibitors of
crystallization. All these observations revealed that EEHS has curative effect on stone formation
induced by ethylene glycol.
 
Date 2009-04-08T10:51:47Z
2009-04-08T10:51:47Z
2009-02
 
Type Article
 
Identifier 0972-592X
http://hdl.handle.net/123456789/3775
 
Language en_US
 
Relation Int. cl.8—A61K 36/00, A61P 13/04
 
Publisher CSIR
 
Source NPR Vol.8(1) [January-February 2009]