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Effects of some flavonoids on the susceptibility of low-density lipoprotein to oxidative modification

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Title Effects of some flavonoids on the susceptibility of low-density lipoprotein to oxidative modification
 
Creator Safari, Mohammad-Reza
Rezaie, Mohsen
Sheikh, Nasrin
 
Subject Flavonoids
oxidative modification
low-density lipoprotein (LDL)
 
Description 358-361
The effects of six flavonoids viz., apigenin, genistein, morin, naringin, pelargonidin and quercetin on the susceptibility of low-density lipoprotein (LDL) to oxidative modification were investigated. Flavonoids were added to plasma and incubated for 3 hr at 37°C, and the LDL fraction was separated by ultracentrifugation. Oxidizability of LDL was estimated by measuring conjugated diene (CD), lipid peroxides and thiobarbituric acid-reactive substances (TBARS), after cupric sulfate solution was added. Quercetin and morin significantly (Pmorin >pelargonidin >genistein >naringin >apigenin. LDL exposed to flavonoids reduced oxidizability. These findings suggest that flavonoids may have a role in ameliorating atherosclerosis.
 
Date 2009-04-13T10:32:37Z
2009-04-13T10:32:37Z
2003-10
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3813
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.40(5) [October 2003]