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Fibronectin dependent upregulation of matrix metalloproteinases in hepatic stellate cells

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Title Fibronectin dependent upregulation of matrix metalloproteinases in hepatic stellate cells
 
Creator Pranitha, P
Sudhakaran, P R
 
Subject Hepatic stellate cells
fibronectin-dependent upregulation
matrix metalloproteinase
 
Description 409-415
Activation and transition of hepatic stellate cells (HSCs) to myofibroblast (MFB)-like cells is influenced by growth factors, cytokines and matrix proteins like fibronectin (FN). To examine whether the FN-dependent transition of HSCs is mediated through FN receptor, a marker function, such as matrix metallo-proteinase (MMP) production by HSCs in primary culture was studied. An upregulation of MMP production by HSCs maintained on FN was observed. FN-dependent upregulation of MMPs was significantly reduced when cells were pre-treated with antibodies to ⍺5β1 integrin. Treatment of cells with genistein, a protein kinase C inhibitor completely blocked the gelatinase production by HSCs, indicating that the FN-dependent upregulation of MMPs is mediated through integrins and it involves tyrosine phosphorylation dependent signaling pathways.
 
Date 2009-04-13T11:46:18Z
2009-04-13T11:46:18Z
2003-12
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3818
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.40(6) [December 2003]