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Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids

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Title Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids
 
Creator Khanduja, K L
Bhardwaj, Anjana
 
Subject antiradical
antioxidant
DPPH
resveratrol
lipid peroxidation
flavonoids
polyphenols
α-tocopherol
 
Description 416-422
Stable free radical scavenging and antiperoxidative activities of resveratrol, a component of grapes and red wine, were evaluated and compared with some other known bioflavonoids (quercetin, catechin, kaempferol, myricetin, fisetin, ellagic acid and naringenin) widely present in the plant kingdom. Free radical scavenging activity was measured in an in vitro chemical system (DPPH assay), while for antiperoxidative activity, biological system comprising of hepatic and pulmonary homogenates was employed. Antiradical activity assay showed quercetin and myricetin to be stronger antiradical agents than resveratrol. Structure-activity study revealed that O-dihydroxy group on ring B of flavonoid plays a crucial role. A double bond at 2-3 position conjugated with a 4-oxo function and hydroxy groups at positions 3 and 5 also contribute towards antiradical activity of flavonoids. Resveratrol exhibited stronger antiradical activity than kaempferol and naringenin and was also more efficient than ⍺-tocopherol, a known strong endogenous non-flavonoid antioxidant, used for comparison. In vitro antiperoxidative assay showed fisetin as the strongest and kaempferol as the weakest antioxidant. Resveratrol was found to be stronger antioxidant than catechin, myricetin, kaempferol and naringenin, but was weaker than quercetin, fisetin and ⍺-tocopherol. Antiradical and antiperoxidative activities of resveratrol may explain its beneficial effects in disease states. Assays exhibited no direct correlation between antiradical and antiperoxidative activities of the phenolics.
 
Date 2009-04-13T11:46:29Z
2009-04-13T11:46:29Z
2003-12
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3819
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.40(6) [December 2003]