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Lipid peroxidation and scavenging enzyme levels in the liver of streptozotocin-induced diabetic rats

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Title Lipid peroxidation and scavenging enzyme levels in the liver of streptozotocin-induced diabetic rats
 
Creator Bukan, Neslihan
Sancak, Banu
Yavuz, Ozlem
Koca, Cemile
Tutkun, Funda
Ozcelikay, A Tanju
Altan, Nilgun
 
Subject lipid peroxidation
antioxidant enzymes
diabetic rats
 
Description 447-450
In this study, alterations in the liver antioxidant enzymes status and lipid peroxidation in short-term (8-weeks) and long-term
(24-weeks) diabetic rats were examined. Glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) levels were significantly increased, but superoxide dismutase (SOD) activity was significantly reduced in 8-weeks diabetic rats, compared to control. Catalase (CAT) activity, however, was found unchanged. In 24-weeks diabetic rats, while GSH-Px activity was unchanged, but SOD and CAT activities and MDA levels were significantly increased, compared to control. These results suggest that diabetes-induced alterations in tissue antioxidant system may reflect a generalized increase in tissue oxidative stress. It can be concluded that lipid peroxidation and antioxidant enzyme levels are elevated in diabetic condition. Hence, diabetes mellitus, if left untreated, may increase degenerative processes due to accumulation of oxidative free radicals.
 
Date 2009-04-13T11:47:33Z
2009-04-13T11:47:33Z
2003-12
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3824
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.40(6) [December 2003]