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Protective effects of propolis on inorganic mercury induced oxidative stress in mice

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Title Protective effects of propolis on inorganic mercury induced oxidative stress in mice
 
Creator Zhao, Jun-Quan
Wen, Yi-Fei
Bhadauria, Monika
Nirala, Satendra Kumar
Sharma, Abhilasha
Shrivastava, Sadhana
Shukla, Sangeeta
Agrawal, Om Prakash
Mathur, Ramesh
 
Subject Hepatoprotection
Lipid peroxidation
Liver
Mercuric chloride
Propolis
 
Description 264-269
Protective potential of propolis was evaluated against mercury induced oxidative stress and antioxidant enzymatic alterations in mice liver. Exposure to mercuric chloride (HgCl2; 5 mg/kg; ip) induced oxidative stress by increasing lipid peroxidation and oxidized glutathione level along with concomitant decrease in glutathione and various antioxidant enzymes. Mercury intoxication deviated the activity of liver marker enzymes in serum. Conjoint treatment of propolis (200 mg/kg; po) inhibited lipid peroxidation and oxidized glutathione level, whereas increased glutathione level. Activities of antioxidants enzymes i.e., superoxide dismutase, catalase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase were also restored concomitantly towards control after propolis administration. Release of serum transaminases, alkaline phosphatase, lactate dehydrogenase and γ-glutamyl transpeptidase were significantly restored towards control after propolis treatment. Results suggest that propolis augments the antioxidants defense against mercury induced toxicity and provides evidence that it has therapeutic potential as hepatoprotective agent.
 
Date 2009-04-16T04:14:21Z
2009-04-16T04:14:21Z
2009-04
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/3859
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(04) [April 2009]