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An efficient method for the synthesis of 2,3-dihydro-1<i>H</i>-isoindoles
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View Archive Info| Field | Value | |
| Title |
An efficient method for the synthesis of 2,3-dihydro-1H-isoindoles
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| Creator |
Subbarayappa, Adimurthy
Patoliya, Paresh U |
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| Subject |
⍺,⍺'-Dibromo-o-xylene
amines sodium hydroxide 2,3-dihydro-1H-isoindoles |
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| Description |
545-552
The synthesis of N-substituted 2,3-dihydro-1H-isoindoles from ⍺, ⍺'-dibromo-o-xylene and various primary amines in basic medium under ambient conditions is described. Especially the selection of 1,4-dioxane as solvent and sodium hydroxide as suitable base to maintain the homogeneity of the medium are key steps to promote the reaction efficiently. Primary alkyl amines react faster as compared to their aromatic analogues under the conditions studied. Irrespective of the starting amine used, all the reactions proceed smoothly and provide 2,3-dihydro-1H-isoindoles derivatives in excellent yields compared to hitherto known methods. |
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| Date |
2009-04-17T04:02:38Z
2009-04-17T04:02:38Z 2009-04 |
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| Type |
Article
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| Identifier |
0376-4699
http://hdl.handle.net/123456789/3867 |
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| Language |
en_US
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| Publisher |
CSIR
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| Source |
IJC-B Vol.48B(04) [April 2009]
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