Record Details

An efficient method for the synthesis of 2,3-dihydro-1<i>H</i>-isoindoles

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title An efficient method for the synthesis of 2,3-dihydro-1H-isoindoles
 
Creator Subbarayappa, Adimurthy
Patoliya, Paresh U
 
Subject ⍺,⍺'-Dibromo-o-xylene
amines
sodium hydroxide
2,3-dihydro-1H-isoindoles
 
Description 545-552
The synthesis of
N-substituted 2,3-dihydro-1H-isoindoles from

⍺,

⍺'-dibromo-o-xylene and various
primary amines in basic medium under ambient conditions is described.
Especially the selection of 1,4-dioxane as solvent and sodium hydroxide as
suitable base to maintain the 
homogeneity of the medium are key steps to promote the reaction
efficiently. Primary alkyl amines react faster as compared to their aromatic
analogues under the conditions studied. Irrespective of the starting amine
used, all the reactions proceed smoothly and provide 2,3-dihydro-1H-isoindoles
derivatives in excellent yields compared to hitherto known methods.
 
Date 2009-04-17T04:02:38Z
2009-04-17T04:02:38Z
2009-04
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/3867
 
Language en_US
 
Publisher CSIR
 
Source IJC-B Vol.48B(04) [April 2009]