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Synthesis and antibacterial activity of 1,3-diaryl-4-cyanopyrazoles

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Title Synthesis and antibacterial activity of 1,3-diaryl-4-cyanopyrazoles
 
Creator Prakash, Om
Pundeer, Rashmi
Ranjan, Pooja
Pannu, Kamaljeet
Dhingra, Yogita
Aneja, K R
 
Subject Vilsmeier-Haack reaction
aldoximes
4-cyanopyrazoles
antibacterial activity
 
Description 563-568
A mild, short and simple method for the small scale synthesis of pharmaceutically important 1,3-diaryl-4-cyanopyrazoles 3 is reported from acetophenone arylhydrazones 1 through a two step reaction. All the title compounds have been subjected to in vitro antibacterial testing against four pathogenic strains namely, S.aureus, B.subtilis (gram positive) and gram negative bacteria namely, P.aeruginosa and E.coli. Preliminary results indicate that most of them exhibited promising activity. Two compounds, namely 1-(4-methylphenyl)-3-(4-bromophenyl)-4-cyanopyrazole 3d and 1-(4-chlorophenyl)-3-phenyl-4-cyanopyrazole 3e from this series are found to be equipotent or more potent than the commercial antibiotics (Linezolid and Ciprofloxacin)
 
Date 2009-04-17T04:25:35Z
2009-04-17T04:25:35Z
2009-04
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/3873
 
Language en_US
 
Publisher CSIR
 
Source IJC-B Vol.48B(04) [April 2009]