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Evaluation of immunomodulatory activity of extracts from marine animals

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Field Value
 
Title Evaluation of immunomodulatory activity of extracts from marine animals
 
Creator Akerkar, Aditya S
Ponkshe, Chetan A
Indap, Madhavi M
 
Subject Animal extracts
Delayed Type
Hypersensitivity
Plaque Forming Cells
 
Description 22-27
The whole body ether extracts of a marine prawn Nematopaleamon tenuipes (PEP), two gastropods viz. Euchelus asper (EAE) and Hemifusus pugilinus (HPE), and acetone extract of a fish Rastrelliger kanagurta (MA), were tested for their effects on Delayed type Hypersensitivity (DTH) reaction and Plaque Forming Cell (PFC) assay. The Delayed type Hypersensitive reaction assay for HPE and PEP as well as MA showed stimulation but EAE was found to be less effective. In the PFC assay HPE and MA showed immunostimulation whereas PEP and EAE showed immunosuppression. PEP was further resolved into two fractions, which were tested for in vitro lymphocyte proliferation assay as well as antiproliferative assay. It is concluded that the test extracts possess immunomodulatory property.
 
Date 2009-05-22T04:49:14Z
2009-05-22T04:49:14Z
2009-03
 
Type Article
 
Identifier 0379-5136
http://hdl.handle.net/123456789/4239
 
Language en_US
 
Publisher CSIR
 
Source IJMS Vol.38(1) [March 2009]