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Evaluation of antiangiogenic activity through tubulin interaction of chloroform fraction of the feather star, <i style="">Lamprometra palmata palmata</i>

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Title Evaluation of antiangiogenic activity through tubulin interaction of chloroform fraction of the feather star, Lamprometra palmata palmata
 
Creator Pandit, Reena
Anil, Annamma
Lali, Arvind
Indap, Madhavi
 
Subject Bioactive
tubulin
antiangiogenic
sea
cell
 
Description 28-37
Tubulin binding agents have received considerable interest as potential tumour-selective angiogenesis-targeting drugs. The present study elucidates that chloroform fraction (CC) isolated from methanol extract of the feather star Lamprometra palmata palmata has a tubulin binding property. With the quantification of chick chorioallantoic (CAM) assay, we further demonstrate that CC significantly and dose-dependently inhibits proliferation, migration of endothelial cells and exhibits antiangiogenic effect with ID50 10ng/10ml. It showed moderate cytotoxicity with IC50 192 mg/ml. In addition, CC arrested onion root tip cells at prometaphase phase. We demonstrate that these effects of CC are attributable to its property to inhibit polymerization of tubulin. These findings show that CC is a candidate antiangiogenic agent and needs further purification for the specific compound, which is responsible for all these activities.
 
Date 2009-05-22T04:49:37Z
2009-05-22T04:49:37Z
2009-03
 
Type Article
 
Identifier 0379-5136
http://hdl.handle.net/123456789/4241
 
Language en_US
 
Publisher CSIR
 
Source IJMS Vol.38(1) [March 2009]