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Marine natural products: A lead for Anti-cancer

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Field Value
 
Title Marine natural products: A lead for Anti-cancer
 
Creator Sarfaraj, Hussain Md.
Sheeba, Fareed
Saba, Ansari
Khan, Mohd. Sajid
 
Subject Marine natural products
didemnin B
Dolastatin
Bryostatin1
Kahalalide F
 
Description 27-39
Various active anticancer agents are derived from plants
and terrestrial microorganisms. Isolation of C-nucleosides from the Caribbean
sponge, Cryptotheca crypta, four decades ago, provided the basis for the
synthesis of cytarabine, the first marine derived anticancer agent to be
developed for clinical use. Cytarabine is currently used in the routine
treatment of patients with leukaemia and lymphoma. Gemcitabine, one of its
fluorinated derivatives, has also been approved for use in patients with
pancreatic, breast, bladder, and non-small-cell lung cancer. Over the past
decade, several new experimental anticancer agents derived from marine sources
have entered preclinical and clinical trials. Present study address anticancer
drug discovery from an evolutionary perspective and present a series of case
studies that demonstrate that the rate of anticancer drug discovery can be increased
greatly by targeted screening of natural compounds from marine sources.
 
Date 2012-01-25T04:18:17Z
2012-01-25T04:18:17Z
2012-02
 
Type Article
 
Identifier 0975-1033 (Online); 0379-5136 (Print)
http://hdl.handle.net/123456789/13453
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJMS Vol.41(1) [February 2012]