Record Details

<i style="mso-bidi-font-style:normal"><span style="font-size:15.0pt;mso-bidi-font-size:11.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Mangal; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-GB">In-vitro</span></i><span style="font-size:15.0pt;mso-bidi-font-size:11.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Mangal; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-GB"> modulation of Na<sup>+ </sup>K<sup>+</sup>, Mg<sup>++</sup> ATP<i style="mso-bidi-font-style:normal">ases</i> and AchE by sea anemone toxic proteins</span>

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title In-vitro modulation of Na+ K+, Mg++ ATPases and AchE by sea anemone toxic proteins
 
Creator Ravindran, Vinoth S
Kannan, L
Venkateshvaran, K
 
Subject Sea anemones
Proteins
Sodium pump
Acetylcholine
Neurotoxins
Enzyme
 
Description 451-456
The crude as well as partially purified
protein fractions of the sea anemone species viz. Heteractis magnifica,
Stichodactyla haddoni and Paracodylactis sinensis, were collected
from the Gulf of Mannar, southeast coast of India. These were found to modulate
the functioning of the sodium pump (Na+ K+, Mg++
ATPase) at the presynaptic
complex of neuro-transmission, thereby affecting ATP hydrolysis. They promote cholinestrase activity at the post synaptic complex by
modulating the activity of the enzyme Acetyl Choline Esterase (AchE).
Modulation was dose dependent. The proteins were toxic to mice.
Histopathological observations reveal that the toxins affected the anatomy of
the brain. Toxin injected mice showed various behavioral changes including
manner shivering of fore limbs, loss of balance, opaque eyes, convulsions,
paralysis, micturiction, flexing of muscles, prodding (insensitive to
stimulii), dragging of hind limbs, rolling of tail, foaming from mouth and
exophthalmia. This could be possibly correlated with CNS dysfunction.


 
Date 2012-10-17T07:35:04Z
2012-10-17T07:35:04Z
2012-10
 
Type Article
 
Identifier 0975-1033 (Online); 0379-5136 (Print)
http://hdl.handle.net/123456789/14878
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJMS Vol.41(5) [October 2012]