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Maintenance and optimization of culture/fermentation media to achieve maximum bioactive metabolites from marine <i>Strptomyces sp</i>. and their cytotoxic effects

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Title Maintenance and optimization of culture/fermentation media to achieve maximum bioactive metabolites from marine Strptomyces sp. and their cytotoxic effects
 
Creator Haque, Md. Anwarul
Imam, Hasan
Hana, Humayera Kabir
Islam, Shaiful
Ganim, Dilruba
Haque, Md. Riazul
 
Subject Strptomyces sp.
Fermentation
Optimization
Bioactive metabolites
Cytotoxicity
 
Description 170-175
Marine soil and sediment samples were collected from different locations of mangrove forest Sundarbans, Bangladesh, the largest tidal halophytic mangrove forest in the world. On the basis of morphological, cultural and biochemical studies, the strain HAN-10 appeared as Streptomyces sp. Optimum cultural composition and fermentation parameters of this marine Streptomyces sp. was determined by the amount of metabolites released and consequently the inhibitory zone diameter measurement by disc diffusion method against Bacillus cereus. Maximum bioactive metabolites was observed when a broth medium containing glucose as carbon source, potassium nitrate, and 3.5% NaCl. Metabolites production was started after four days of incubation, reached its maximum levels after eight days, sustained upto ten days and thereafter gradually decreased. 37o C temperature and 6-7 pH was maintained for its optimum growth and metabolite release.
 
Date 2017-03-02T05:50:21Z
2017-03-02T05:50:21Z
2017-01
 
Type Article
 
Identifier 0975-1033 (Online); 0379-5136 (Print)
http://nopr.niscair.res.in/handle/123456789/40603
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJMS Vol.46(01) [January 2017]