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Inhibition of local effects of Indian <i style="">Daboia/Vipera russelli</i> venom by the methanolic extract of grape (<i style="">Vitis vinifera</i> L.) seeds

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Title Inhibition of local effects of Indian Daboia/Vipera russelli venom by the methanolic extract of grape (Vitis vinifera L.) seeds
 
Creator Mahadeswaraswamy, Y H
Devaraja, S
Kumar, M S
Goutham, Y N J
Kemparaju, K
 
Subject Hyaluronidase
Local effects
Metalloprotease
Neutralization
Snake venom
Proteolytic activity
Hemorrhagic activity
Edema-inducing activity
Myonecrotic activity
Fibrinogenolytic activity
Pro-coagulant activity
Daboia russelli
Vipera russelli
Grape seed
Vitis vinifera L.
 
Description 154-160
Although anti-venom therapy is available for the treatment of fatal bite by snakes, it offers less or no protection against the local effects such as dermo- and myonecrosis, edema, hemorrhage and inflammation at the bitten region. The viper species are known for their violent local effects and such effects have been commonly treated with plant extracts without any scientific validation in rural India. In this investigation, the methanolic extract of grapes (Vitis vinifera L.) seed was studied against the Indian Daboia/Vipera russelli venom-induced local effects. The extract abolished the proteolytic and hyaluronidase activities and also efficiently neutralized the hemorrhage, edema-inducing and myonecrotic properties of the venom. In addition, the extract also inhibited partially the pro-coagulant activity of the venom and abolished the degradation of Aα and Bβ chains of human fibrinogen. Thus, the extract possesses potent anti-snake venom property, especially against the local effects of viper bites.
 
Date 2009-05-01T03:48:25Z
2009-05-01T03:48:25Z
2009-04
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/4051
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.46(2) [April 2009]