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Antioxidant status in polycystic end-staged renal diseased patients and antihemolytic effect of <i style="">Boerhaavia diffusa</i>

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Title Antioxidant status in polycystic end-staged renal diseased patients and antihemolytic effect of Boerhaavia diffusa
 
Creator Sathyapriya, K
Vijayachandrika, V
Parameswari, C S
 
Subject Hemodialysis
Erythrocytes
Boerhaavia diffusa
End-staged renal disease
Antioxidant status
Antihemolytic activity
 
Description 269-272
Chronic renal failure (CRF) induces anaemia by shortening the life-span of erythrocytes, due to an increase in oxidative stress, which is considered to be one of the major risk factors in CRF patients undergoing hemodialysis. In the present study, the antioxidant status of the end-staged renal disease (ESRD) patients was investigated. The antihemolytic activity of Boerhaavia diffusa on the erythrocytes of the patients was also studied. Protein, lipid peroxides (LPO), reduced glutathione (GSH) levels and glutathione peroxidase (GPX) and glutathione-S-transferase (GST) activities were measured in the hemolysate from 55 polycystic ESRD patients (Group II) and compared with normal subjects (Group I). The antioxidant status was found to be significantly reduced in the patients as compared to normal healthy volunteers, due to increased oxidative stress. Also, aqueous extract of B. diffusa showed a significant antihemolytic activity on the erythrocytes of the polycystic ESRD patients.

 
 
Date 2009-06-15T12:07:02Z
2009-06-15T12:07:02Z
2009-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/4591
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.46(3) [June 2009]