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Serum biochemical markers in rheumatoid arthritis

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Field Value
 
Title Serum biochemical markers in rheumatoid arthritis
 
Creator Pallinti, Vasanthi
Ganesan, Nalini
Anbazhagan, M
Rajasekhar, G
 
Subject Homocysteine
Adenosine deaminase
Cortisol
Oxidative stress
Rheumatoid arthritis
 
Description 342-344
Rheumatoid arthritis (RA) characterized by local and systemic effects of inflammation has a wide range of biochemical markers implicated directly or indirectly to its pathogenesis. In the present study, homocysteine, cortisol, adenosine deaminase (ADA), ferritin, malondialdehyde (MDA) and -tocopherol in serum of RA patients and healthy individuals were estimated to assess if they contribute to the disease process. The markers of disease activity such as erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF) were also measured. The study group included a total of 45 subjects, including 30 RA patients and the rest being healthy individuals. RA group showed a significant increase in the levels of homocysteine, ADA and MDA, and a significant decrease in α-tocopherol compared to the healthy individuals. However, cortisol and ferritin levels did not show any significant change. Also, there was no significant correlation between the studied serum markers and markers of disease activity. Our results indicate that these biochemical markers contribute independently to the pathogenesis of RA.
 
Date 2009-08-06T12:08:48Z
2009-08-06T12:08:48Z
2009-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/5804
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.46(4) [August 2009]