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Oxidative Stress in Cardiovascular Disease

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Field Value
 
Title Oxidative Stress in Cardiovascular Disease
 
Creator Lakshmi, S V Vijaya
Padmaja, G
Kuppusamy, Periannan
Kutala, Vijay Kumar
 
Subject Free radicals
Oxidative stress
Cardiovascular diseases
Antioxidants
Reactive oxygen species
Hypertension
Blood pressure
 
Description 421-440
Over the last two decades, it has become increasingly clear that reactive oxygen species (ROS), including free radicals are involved in cardiovascular disease. In recent years, there has been a growing interest in the clinical implications of these oxidants. The ROS are common by-products of many oxidative biochemical and physiological processes. They can be released by xanthine oxidase, NAD(P)H oxidase, lipoxygenases, mitochondria, or the uncoupling of nitric oxide synthase in vascular cells. ROS mediate various signaling pathways that underlie vascular inflammation in atherogenesis. Various animal models of oxidative stress support that ROS have causal role in atherosclerosis and other cardiovascular diseases. They are too reactive to be tolerated in living tissue, and aerobic organisms use sophisticated defense system, both enzymatic and non-enzymatic for prevention of overload of free radicals. In a number of pathophysiological conditions, the delicate equilibrium between free-radical production and antioxidant capability can be altered in favor of the former, thus leading to oxidative stress and increased tissue injury. This review focuses on the biochemical evidences concerning involvement of ROS in several cardiovascular diseases, namely atherosclerosis, heart failure, hypertension and ischemia/reperfusion injury.
 
Date 2010-01-25T05:44:48Z
2010-01-25T05:44:48Z
2009-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/7246
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.46(6) [December 2009]