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<i style="">In vitro</i> antioxidant activity of <i>Hedyotis corymbosa </i>(L.) Lam. aerial parts

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Title In vitro antioxidant activity of Hedyotis corymbosa (L.) Lam. aerial parts
 
Creator Sasikumar, J M
Maheshu, V
Aseervatham, G Smilin Bell
Darsini, D Teepica Priya
 
Subject Hedyotis corymbosa
Antioxidant activity
Ferric reducing power
ABTS
Nitric oxide scavenging activity
DPPH
 
Description 49-52
The methanolic extract of the aerial part of Hedyotis corymbosa (L.) Lam. (Rubiaceae) was screened for antioxidant activity using 1,1-diphenyl-2-picryl hydroxyl (DPPH) quenching assay, 2,2’-azinobis-3-ethylbenzothiozoline-6-sulfonic acid (ABTS) cation decolorization test, ferric reducing power (FRP), scavenging capacity towards hydroxyl ion (OH·) radicals and nitric oxide (NO) radical inhibition activity using established assay procedures. Total phenolics and total flavonoid contents were also determined. The plant yielded 210 mg gallic acid equivalent/100 g phenolic content and 55 mg quercetin equivalent/100 g flavonoid content. The extract exhibited high antiradical activity against DPPH, ABTS, nitric oxide and hydroxyl radicals with EC50 value of 82, 150, 130, and 170 µg/ml, respectively. The FRP increased with increasing concentration of the sample. The antioxidant activity of the extract was comparable with that of the standard butylated hydroxyl toluene (BHT). High correlation between total phenolic/flavonoid contents and scavenging potential of different reactive oxygen species (R2 = 0.785-0.998) indicated the polyphenols as the main antioxidants.
 
Date 2010-02-24T06:42:54Z
2010-02-24T06:42:54Z
2010-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/7464
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.47(1) [February 2010]