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Isolation of 1,4-naphthalenedione, an antibacterial principle from the leaves of<i style=""> Holoptelea integrifolia </i>and its activity against β-lactam resistant <i style="">Staphylococcus aureus </i>

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Title Isolation of 1,4-naphthalenedione, an antibacterial principle from the leaves of Holoptelea integrifolia and its activity against β-lactam resistant Staphylococcus aureus
 
Creator Vinod, N V
Haridas, M
Sadasivan, C
 
Subject Staphylococcus aureus
Antibacterial activity
Holoptelea integrifolia
β-Lactam antibiotics
GC-MS
FTIR
 
Description 53-55
Antimicrobials derived from plants have been receiving increasing attention in recent years. Antimicrobial activities of a number of phytochemicals have been reported. Many present day antibiotics are ineffective against several pathogenic organisms. About 90% of Staphylococcus aureus isolates from clinical specimens is reported to have resistance against β-lactam antibiotics. In the present study, the effect of hexane, diethyl ether, acetone and water extracts of leaves of a medicinal plant Holoptelea integrifolia has been tested against β-lactam resistant strain of S. aureus in presence of antibiotics such as ampicillin, amoxicillin, cefotaxime and ceftriaxone. The diethyl ether extract has shown the maximum antibacterial activity and the active principle is found to be 1,4-naphthalenedione which is characterized by GC-MS and FTIR spectroscopy. The minimum inhibitory concentration (MIC) of the compound is found to be 4 mg/ml. Structural similarity of this compound with a func- tional group of a β-lactamase-resistant antibiotic indicates that 1,4-naphthlenedione may be acting as an inhibitor to β-lactamase.
 
Date 2010-02-24T06:44:58Z
2010-02-24T06:44:58Z
2010-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/7467
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.47(1) [February 2010]