Record Details

Preparation and characterization of biopolymeric nanoparticles used in drug delivery

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Preparation and characterization of biopolymeric nanoparticles used in drug delivery
 
Creator Ramachandran, Radhika
Shanmughavel, Piramanayagam
 
Subject Gelatin
Nanoparticles
Nanotechnology
Sulfadiazine
Cross-linker
Cysteine
 
Description 56-59
Nanotechnology plays an important role in advanced biology and medicine research particularly in the development of potential site-specific delivery systems with lower drug toxicity and greater efficiency. These include microcapsules, liposomes, polymeric microspheres, microemulsions, polymer micelles, hydrogels, solid nanoparticles etc. In the present study, preparation and characterization of biopolymeric gelatin nanoparticles for encapsulating the antimicrobial drug sulfadiazine and its in vivo drug release in phosphate buffer saline (PBS) have been investigated. The nanoparticles prepared by second desolvation process varied in a size range 200 nm and 600 nm with a drug entrapment efficiency of 50% characterized by atomic force microscopy and dynamic light scattering. The drug release from the nanoparticles occurred up to 30% in a controlled manner.
 
Date 2010-02-24T06:46:53Z
2010-02-24T06:46:53Z
2010-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/7469
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.47(1) [February 2010]