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Attenuation of renal dysfunction by anti-hyperglycemic compound isolated from fruit pulp of <i style="">Eugenia jambolana </i>in streptozotocin-induced diabetic rats

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Title Attenuation of renal dysfunction by anti-hyperglycemic compound isolated from fruit pulp of Eugenia jambolana in streptozotocin-induced diabetic rats
 
Creator Tanwar, Reenu Singh
Sharma, Suman Bala
Singh, Usha Rani
Prabhu, Krishna Madhava
 
Subject Eugenia jambolana
Diabetes mellitus
Streptozotocin
Nephroprotective activity
 
Description 83-89
The renal protective effect of an active
principle isolated from the aqueous extract of fruit pulp of Eugenia jambolana was investigated in
streptozotocin(45 mg/kg body weight)-induced severely diabetic rats (FBG ≥  300 mg/dl). For isolation of active principle,
crude aqueous extract of E. jambolana
fruit pulp was subjected to purification by ion-exchange column chromatography,
which yielded a partially purified compound (FII), which on further
purification by rechromatography gave a purified active compound (FIIc). Purity
of FIIc was confirmed by high pressure liquid chromatography. Detailed UV, NMR,
IR spectra suggested that FIIc is a small aliphatic organic compound having
molecular formula C4H7O4N. Oral administration
of FIIc to diabetic rats (10, 15 and 20 mg/kg body weight per day for a period
of 60 days) produced significant (P
 
Date 2010-04-23T04:12:17Z
2010-04-23T04:12:17Z
2010-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/8267
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.47(2) [April 2010]