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Evaluation of anti-allergic activity of gossypin and suramin in mast cell-mediated allergy model

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Title Evaluation of anti-allergic activity of gossypin and suramin in mast cell-mediated allergy model
 
Creator Ganapaty, S
Chandrashekhar, V M
Narsu, M Laxshmi
 
Subject Gosyypin
Suramin
Allergic reactions
Compound 48/80
Histamine
Mast cells
 
Description 90-95
The mast
cell-mediated allergic reactions are involved in many allergic diseases, such
as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells initiates
the process of degranulation, resulting in the release of mediators such as
histamine and an array of inflammatory cytokines. In this report, we
investigated the effect of gossypin (a biflavonoid) and suramin (a synthetic
polysulphonated naphtylurea) on the mast cell-mediated allergy model, and
studied the possible mechanism of their action. Both gossypin and suramin
inhibited (P
 
Date 2010-04-23T04:12:37Z
2010-04-23T04:12:37Z
2010-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/8268
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.47(2) [April 2010]