Record Details

Hypolipidemic and antioxidant activity of <i style="">Anthocephalus indicus </i>(Kadam) root extract

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Hypolipidemic and antioxidant activity of Anthocephalus indicus (Kadam) root extract
 
Creator Kumar, Vishnu
Mahdi, Farzana
Chander, Ramesh
Singh, Ranjana
Mahdi, Abbas Ali
Khanna, Ashok Kumar
Bhatt, Sanjay
Kushwaha, Rajeev Singh
Jawad, Kalbe
Saxena, Jitendra Kumar
Singh, Raj Kumar
 
Subject Cholic acid
Deoxycholic acid
Lipid peroxides
Superoxide dismutase
Catalase
Lipoprotein lipase
Triglyceride lipase
Lecithin cholesterol acyltransferase
 
Description 104-109
The present
study was carried out to explore the anti-diabetic, anti-dyslipoproteinemic and
anti-oxidant activities of Anthocephalus indicus root extract in
alloxan-induced (150 mg/kg body wt.) diabetic rats. A marked increase in plasma
levels of glucose and lipid peroxides accompanied with an elevation in the
lipids and apoprotein levels of serum very low density lipoprotein (VLDL) and
low density lipoprotein (LDL) following decrease in lipid and protein
constituents of high density lipoprotein (HDL) were observed. The alterations
in lipoprotein pattern was associated with inhibition of lipolytic and
antioxidant enzymes. Oral administration of root extract (500 mg/kg body wt.)
for 30 days in dyslipidemic animals resulted in significant decrease in plasma
glucose, total cholesterol, phospholipids, triglyceride and lipid peroxides.
The decrease of lipids and apoprotein levels of VLDL and LDL were followed by
stimulation of plasma post-heparin lipolytic activity and lecithin cholesterol acyltransferase
as well as hepatic superoxide dismutase and catalase activities. Lipid and
apoprotein levels of HDL were also recovered partially on treatment with root
extract.
 
Date 2010-04-23T04:13:27Z
2010-04-23T04:13:27Z
2010-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/8270
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.47(2) [April 2010]