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Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: Attenuation by <i>Withania somnifera</i>

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Title Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: Attenuation by Withania somnifera
 
Creator Yadav, C S
Kumar, V
Suke, S G
Ahmed, R S
Mediratta, P K
Banerjee, B D
 
Subject Carbamate
Propoxur
Withania somnifera
Behavioral toxicity
Transfer latency
Acetylcholineestrase (AChE)
Cognitive function
Tissue toxicity
 
Description 117-120
Propoxur
(2-isopropoxyphenyl N-methylcarbamate) is widely used as an acaricide in
agriculture and public health programs. Studies have shown that sub-chronic
exposure to propoxur can cause oxidative stress and immuno-suppression in rats.
Carbamates are also known to exhibit inhibitory effect on cholinesterase
activity, which is directly related to their cholinergic effects. In the
present study, the effect of Withania somnifera (Ashwagandha), a widely
used herbal drug possessing anti-stress and immuno-modulatory properties was
studied on propoxur-induced acetylcholine esterase inhibition and impairment of
cognitive function in rats. Male Wistar rats were divided into four groups.
Group I was treated with olive oil and served as control. Group II was
administered orally with propoxur (10 mg/kg b.wt.) in olive oil, group III
received a combination of propoxur (10 mg/kg b.wt.)
and W. somnifera (100 mg/kg b.wt.) suspension and group IV
W.
somnifera (100 mg/kg b.wt.) only. All animals were treated for
30 days. Cognitive behaviour was assessed by transfer latency using elevated
plus maze. Blood and brain acetylcholine esterase (AChE) activity was also
assessed. Oral administration of propoxur
(10 mg/kg b.wt.) resulted in a significant reduction of brain and blood AChE
activity. A significant prolongation of the acquisition as well as retention
transfer latency was observed in propoxur-treated rats. Oral treatment of W.
somnifera exerts protective effect and attenuates AChE inhibition and
cognitive impairment caused by sub-chronic exposure to propoxur.
 
Date 2010-04-23T04:15:13Z
2010-04-23T04:15:13Z
2010-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/8274
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.47(2) [April 2010]