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Hepatoprotective activity of leaves of <i style="">Zanthoxylum armatum</i> DC in CCl<sub>4</sub> induced hepatotoxicity in rats

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Title Hepatoprotective activity of leaves of Zanthoxylum armatum DC in CCl4 induced hepatotoxicity in rats
 
Creator Verma, Nitin
Khosa, R L
 
Subject Zanthoxylum armatum
Hepatoprotective activity
 
Description 124-127
Zanthoxylum
armatum DC (Rutaceae) is extensively used in
indigenous system of medicine as a tonic, carminative, stomachic and
anthelmintic. In the present study, the hepatoprotective
activity of the leaves ethanolic extract of Z. armatum (EEZA) was evaluated in CCl4-induced
hepatotoxicity in rats. The extract at a dose of 500 mg/kg registered a significant decrease in
the levels of serum glutamyl
oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT),
alkaline phosphatase (ALKP), and serum bilurubin (SBLN) and liver inflammation, which was supported by histopathological
studies on liver,
thus exhibited a significant hepatoprotective activity. The phytochemical
screening of defatted ethanolic extract showed the presence of sterols,
alkaloids, flavonoids, and reducing sugars.
 
Date 2010-04-23T04:07:52Z
2010-04-23T04:07:52Z
2010-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/8265
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.47(2) [April 2010]