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<i>In vitro</i> studies on inhibitory effect of proanthocyanidins in modulation of neutrophils and macrophages

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Title In vitro studies on inhibitory effect of proanthocyanidins in modulation of neutrophils and macrophages
 
Creator Govindaraj, Jayamathi
Emmadi, Pamela
Puvanakrishnan, Rengarajulu
 
Subject Lysosomal enzymes
Macrophages
Neutrophils
Proanthocyanidins
Reactive nitrogen species
Reactive oxygen species
 
Description 141-147
The role of proanthocyanidins (PC), a novel
flavonoid extracted from grape seeds was studied in vitro in the
modulation of neutrophil and macrophage function. We attempted to assess the
levels of non-enzymatic and enzymatic mediators in the presence or absence of
PC in 4-phorbol-12--myristate-13-acetate (PMA)-stimulated
neutrophils isolated from humans and rats, E. coli endotoxin-stimulated
macrophages and macrophages isolated from E. coli
endotoxin-induced experimental periodontitis in rats. Addition of PC at
a concentration of 50 µg/ml effectively blocked the release of reactive oxygen
species (ROS) and reactive nitrogen species (RNS) and exhibited a marked
inhibition of myeloperoxidase (MPO) and lysosomal enzymes (p
 
Date 2010-06-30T09:45:23Z
2010-06-30T09:45:23Z
2010-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/9810
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.47(3) [June 2010]