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Long-term caloric restriction up-regulates PPAR gamma co-activator 1 alpha (PGC-1<img src='/image/spc_char/alpha.gif' border=0> ) expression in mice

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Title Long-term caloric restriction up-regulates PPAR gamma co-activator 1 alpha (PGC-1 ) expression in mice
 
Creator Ranhotra, Harmit S
 
Subject PGC-1
Metabolism
Caloric restriction
Mice
 
Description 272-277
The peroxisome proliferator-activated
receptor (PPAR) gamma co-activator 1 alpha (PGC-1 ), a signal-sensing transcriptional co-activator in association with
many nuclear receptors regulates various genes that control energy balance in animals.
In this study, the effect of long-term caloric restriction (CR) (alternate days
of fasting for 3 months) on the expression of PGC-1 protein in various tissues was investigated in mice. Western blot
analyses showed positive immunoreactive PGC-1 (~92 kDa) signal from various tissues. Heart, kidney and skeletal
muscles expressed significant levels of PGC-1 , while a comparatively lower level was detected in the liver, small
intestine and brain. The expression of PGC-1 was the highest and lowest in the heart and liver respectively. CR
mice exhibited a significant increase in PGC-1a level in the heart (5.13-fold), kidney (3.57-fold), skeletal muscle
(3.02-fold), liver (2.60-fold), small intestine (2.45-fold) and brain
(2.05-fold), compared to normal (ad
libitum) fed. The elevation
in PGC-1 level, especially in highly oxidative
tissues such as heart, kidney and skeletal muscle of CR mice might
synergistically up-regulate genes that require PGC-1
co-activation. Taken together, the up-regulation of PGC-1 expression might potentially support optimal energy metabolism and
biochemical adaptation, necessary for maintaining energy homeostasis during
long-term CR.
 
Date 2010-11-02T10:26:24Z
2010-11-02T10:26:24Z
2010-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/10520
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.47(5) [October 2010]