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Cadmium-induced oxidative stress in <i>Saccharomyces cerevisiae</i>

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Title Cadmium-induced oxidative stress in Saccharomyces cerevisiae
 
Creator Muthukumar, Kannan
Nachiappan, Vasanthi
 
Subject Cadmium
Superoxide dismutase
Catalase
Glutathione
Glutathione peroxidase
Saccharomyces cerevisiae
 
Description 383-387
The
present study was undertaken to determine the effect of cadmium (Cd) on the
antioxidant status of the yeast Saccharomyces
cerevisiae. S. cerevisiae serves
as a good eukaryotic model system for the study of the molecular mechanisms of
oxidative stress. We investigated the adaptative response of S. cerevisiae exposed to Cd. Yeast cells
could tolerate up to 100 μM Cd and an inhibition in the growth and viability
was observed. Exposure of yeast cells to Cd showed an increase in malondialdehyde and glutathione. The activities of catalase,
superoxide dismutase and glutathione peroxidase were also high in Cd-exposed
cells. The incorporation of Cd led to significant increase in iron, zinc and
inversely the calcium, copper levels were reduced. The results suggest that
antioxidants were increased and are involved in the protection against
macromolecular damage during oxidative stress; presumably, these enzymes are
essential for counteracting the pro-oxidant effects of Cd.
 
Date 2011-01-07T09:44:25Z
2011-01-07T09:44:25Z
2010-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/10863
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.47(6) [December 2010]