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Induction of oxidative stress and histopathological changes by sub-chronic doses of triazophos

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Title Induction of oxidative stress and histopathological changes by sub-chronic doses of triazophos
 
Creator Jain, Smita
Mythily, S
Ahmed, Rafat S
Arora, Vinod K
Banerjee, B D
 
Subject Triazophos
Oxidative stress
Lipid peroxidation
Glutathione
Glutathione-S-transferase
Ferric reducing ability of plasma
 
Description 388-392
The effect of triazophos (O, O-diethyl O-1-phenyl-1
H-1,
2, 4-triazol-3-yl phosphorothioate), a widely used insecticide was studied on
the induction of oxidative stress and histological alterations at sub-chronic
doses in male albino rats. Oral administration of triazophos at concentrations
of 1.64, 3.2 and 8.2 mg/kg body wt for 30 days produced dose as well as
time-dependent increase in the lipid peroxidation (determined by
malondialdehyde levels) and glutathione-S-transferase (GST) activity in serum
with a concomitant decrease in ferric reducing ability of plasma (FRAP) and
blood glutathione (GSH) content. Histopathological examination of liver of
triazophos-treated rats showed significant and progressive degenerative changes
as compared to control, which could be due to induction of oxidative stress.
However, no significant histopathological changes were observed in spleen,
kidney and brain at either dose of triazophos with respect to control. These
results indicated that oral administration of triazophos was associated with
enhanced lipid peroxidation and compromised antioxidant defence in rats in dose
and time-dependent manner. Thus the present study demonstrated for the first
time the role of oxidative stress as the important mechanism involved in the
stimulation of hepatic histo-architectural alterations at sub-chronic doses of
triazophos in rats.
 
Date 2011-01-07T09:45:02Z
2011-01-07T09:45:02Z
2010-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/10864
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.47(6) [December 2010]