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MsbA ATP-binding cassette (ABC) transporter of <i>E. coli</i>: Structure and possible flippase mechanism

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Title MsbA ATP-binding cassette (ABC) transporter of E. coli: Structure and possible flippase mechanism
 
Creator Kaul, Gautam
Pattan, Gurulingappa
 
Subject Structure
MsbA
ATP-binding cassette transporter
ATP hydrolysis
Flip-flop
E. coli
 
Description 7-13
ATP-binding cassette (ABC) transporters
utilize the energy present in cellular ATP to drive the translocation of
structurally diverse set of solutes across the membrane barriers of eubacteria,
archaebacteria and eukaryotes. In bacteria, these transporters are considered
to be important virulence factors because they play role in nutrient uptake and
in the secretion of toxins. The advances in structural determination and
functional analysis of bacterial transporters have greatly increased our
understanding of the mechanism of transport of these ABC transporters. Although
progress in the field of structural biology has been made with the prokaryotic
family members, it is likely that eukaryotic transporters will utilize the same
mechanisms for translocation process. In this review, we summarize the function
of the known MsbA ABC transporters in E.
coli and mechanistic insights from structural and possible flippase
mechanism studies.
 
Date 2011-02-25T04:13:07Z
2011-02-25T04:13:07Z
2011-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/11099
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.48(1) [February 2011]