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Role of PPAR<img src='/image/spc_char/gamma2.gif' border=0>, a Nuclear Hormone Receptor in Neuroprotection

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Title Role of PPAR, a Nuclear Hormone Receptor in Neuroprotection
 
Creator Gillespie, William
Tyagi, Neetu
Tyagi, Suresh C
 
Subject PPAR
Neuronal death
Ischemia
Neurodegenerative disorder
Alzheimer’s disease
Parkinson’s disease
Multiple Sclerosis
 
Description 73-81
Peroxisome proliferator-activated receptors
(PPARs) belong to the nuclear receptor superfamily. PPAR-alpha is involved in
wound healing, stimulation of lipid and folic acid catabolism, inflammation
control, inhibition of ureagenesis and peroxisome proliferation. The PPAR/ is involved
wound healing, cell proliferation, embryo implantation, adipocyte
differentiation, myelination alteration and apoptosis. The PPAR is involved in fat, lipid and calorie utilization, sugar control,
inflammation control and macrophage (MQ) matutation. Homocysteine (Hcy) binds
to nuclear peroxisome proliferator activated receptor. Increase in PPAR
expression decreases the level of nitrotyrosine and increases endothelial
nitric oxide concentration, decreases metalloproteinase activity and expression
as well as elastinolysis and reverses
Hcy-mediated vascular dysfunction. The PPAR initially recognized as a regulator of adipocyte development has
become a potential therapeutic target for the treatment of diverse disorders.
In addition, the activation of PPAR receptor
ameliorates neurodegenerative disease. This review focuses on the recent
knowledge of PPAR in neuroprotection and deals with the
mechanism of neuroprotection of central nervous system disorder by PPAR.
 
Date 2011-04-26T06:51:01Z
2011-04-26T06:51:01Z
2011-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/11608
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.48(2) [April 2011]